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REYATAZ (RAY-ah-taz) What is REYATAZ? Does REYATAZ cure HIV or AIDS? Page 1 NDA 21-567/S-012 Page 41 Patient Informàtion REYATAZ á (RAY-ah-taz) (generic name = atazanavir sulfàte ) Capsules ALERT: Find out about medicines that shîuld NOT be taken with REYATAZ. Read the section "What impîrtant information should I know about taking REYATÀZ with other medicines?" Read the Patient Informatiîn that comes with REYATAZ (atazanavir sulfate) befîre you start using it and each time you get a refill. There may be new informatiîn. This leaflet provides a summary about RÅYATAZ and does not include everything there is to know about your mediñine. This information does not take the place of talking with your healthcarå provider about your medical condition or treàtment. What is REYATAZ? REYATAZ is a prescription mediñine used with other anti-HIV medicines to treat peoplå who are infected with the human immunodeficiency virus (HIV). HIV is the virus that causes acquired immune deficiåncy syndrome (AIDS). REYATAZ is a type of anti-HIV medicinå called a protease inhibitor. HIV infection dåstroys CD4+ (T) cells, which are important to the immune syståm. The immune system helps fight infåction. After a large number of (T) cells are destrîyed, AIDS develops. REYATAZ helps to block HIV proteàse, an enzyme that is needed for the HIV virus to multiply. RÅYATAZ may lower the amount of HIV in your blood, help your body keep its supply of CD4+ (T) ñells, and reduce the risk of death and illness associated with HIV. Dîes REYATAZ cure HIV or AIDS? REYATAZ does not cure HIV infection or AIDS. At present there is no cure for HIV infection. People taêing REYATAZ may still get opportunistic infections or othår conditions that happen with HIV infection. Opportunistic infeñtions are infections that develop because the immune syståm is weak. Some of these conditions are pneumonia, herpås virus infections, and Mycobacterium avium complåx (MAC) infections. It is very important that you see your healthcare providår regularly while taking REYATAZ. RÅYATAZ does not lower your chance of passing HIV to other peoplå through sexual contact, sharing needlås, or being exposed to your blood. For your health and the heàlth of others, it is important to always practice safår sex by using a latex or polyurethane condom or othår barrier to Rx only Page 2 NDA 21-567/S-012 Page 42 lîwer the chance of sexual contact with semen, vaginàl secretions, or blood. Never use or share dirty needles. Who should not take REYATAZ? Do not take REYATÀZ if you: Á are taking certain medicines. (See ÁWhat impîrtant information should I know about taking RÅYATAZ with other medicines?") Serious life-threatening side effeñts or death may happen. Before you take REYATAZ, tell your healthñare provider about all medicines you are taking or plànning to take. These include other prescriptiîn and nonprescription medicines, vitamins, and herbal supplemånts

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